Chordoid
glioma (CG) is a rare slowly growing tumor which is usually located in third
ventricle of adults. Firstly described as a new pathologic entity by Brat et
al. in 1998. It was introduced the World Health Organization (WHO)
classification of nervous system tumors in 2000. On the basis of limited
clinico-pathological data this neoplasm has been classified as a low grade
corresponding to WHO grade II. Chordoid glioma was so named because of its
histologic features resembling a chordoma and because of its immunoreactivity
to GFAP.
Histologically it is characterized by clusters and cords of
epithelioid tumor cells which express GFAP and which possess a mucinous stroma
typically containing a lymphoplasmacytic infiltrate. Actually the first case described
by Wanschitz et al. was a solid, third ventricular tumor occurring in a 24 year
old woman. The authors concluded that the tumor was a meningioma with peculiar
expression of GFAP. Subsequent immunohistochemical and ultrastructural studies
of similar cases have not supported a meningothelial derivation; rather
evidence indicates that they are glial in nature. Mitosis are rare and MIB-1
index is always lower than 5% in CG. Read more>>>>>>>>>>>>>>>>
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